現(xiàn)貨moradec AM-102-AE說(shuō)明書

更新時(shí)間：2022-12-28

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現(xiàn)貨moradec AM-102-AE說(shuō)明書

αMFc CL MMAE

具有可裂解連接子的抗小鼠IgG Fc MMAE抗體

目錄號(hào)：AM-102-AE

αMFc CL MMAE是一種抗小鼠IgG Fc特異性抗體，通過(guò)可裂解的接頭與單甲基auristatin E（MMAE）偶聯(lián)。抗體部分是對(duì)小鼠IgG的Fc區(qū)具有特異性的多克隆抗體，并且它也對(duì)大鼠IgG的Fc區(qū)具有交叉反應(yīng)性。單甲基auristatin E（MMAE）是一種細(xì)胞毒性小分子，通過(guò)阻斷微管蛋白的聚合來(lái)抑制細(xì)胞分裂。連接MMAE和抗體的可裂解接頭在細(xì)胞外液中是穩(wěn)定的，但一旦綴合物通過(guò)內(nèi)吞作用進(jìn)入細(xì)胞，就會(huì)被內(nèi)體中的組織蛋白酶裂解。

αMFc-CL-MMAE

Anti-Mouse IgG Fc-MMAE Antibody with Cleavable Linker

Catalog Number: AM-102-AE

αMFc-CL-MMAE is anti-mouse IgG Fc specific antibody conjugated to monomethyl auristatin E (MMAE) with a cleavable linker. The antibody portion is a polyclonal antibody which is specific to the Fc region of mouse IgGs, and it is also cross-reactive to the Fc region of Rat IgGs. Monomethyl auristatin E (MMAE) is a cytotoxic small molecule which inhibits cell division by blocking the polymerization of tubulin. The cleavable linker connecting MMAE to the antibody is stable in extracellular fluid, but is cleaved by cathepsin in endosome once the conjugate has entered a cell via endocytosis.

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